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what is lasix used for in dogs Cisplatin has been associated with cardiac AEs including chest pain occurring at a rate as high as 40 and believed to be due to endothelial dysfunction and altered vasoreactivity; coronary thrombosis even in patients without underlying atherosclerosis; arrhythmias; acute ischemic events including ischemia of limbs and myocardial infarction MI secondary to abnormal vasoreactivity; and stroke may be caused by endothelial cell death and production of procoagulant microparticles